SIP1 Monoclonal Antibody (6E5), Active Motif™

Mouse Monoclonal Antibody

Supplier:  Active Motif 61095

Catalog No. 50-199-3137

Description

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

Specifications

• Antigen: SIP1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Accession No.: O60315
• Gene Symbols: Zeb2
• Immunogen: This SIP1 antibody was raised against a recombinant protein corresponding to amino acids 1-360 of human SIP1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 6E5
• Conjugate: Unconjugated
• Gene: Zeb2
• Gene Alias: 9130203F04Rik; BOS_1771; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; Sip1; SIP-1; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; Zeb2; Zfhx1b; ZFX1B; Zfxh1b; zinc finger E-box binding homeobox 2; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 9839
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid