Invitrogen™ SIPA1L1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551761

Catalog No. PIPA551761

Description

Immunogen sequence: IRQRSNSDIT ISELDVDSFD ECISPTYKTG PSLHREYGST SSIDKQGTSG ESFFDLLKGY KDDKSDRGPT PTKLSDFLIT GGGKGSGFSL DVIDGPISQR ENLRLFKERE KPLKRRSKSE TGDSSIFRKL RNAKGEELGK SSDLEDNRSE Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.

Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.

Specifications

• Antigen: SIPA1L1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIPA1L1
• Gene Alias: 4931426N11Rik; AW213287; E6-targeted protein 1; E6TP1; H_DJ1140G11.1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1; Kiaa0440; mKIAA0440; signal induced proliferation associated 1 like 1; signal-induced proliferation-associated 1 like 1; signal-induced proliferation-associated 1-like protein 1; SIPA1L1; SIPA1-like protein 1; Spa1; Spa-1; SPA-1 like protein p1294; SPA-1-like protein p1294; SPAL; Spar; Spine-associated Rap GTPase-activating protein; spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP); WUGSC:H_DJ1140G11.1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26037
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O43166
• Gene Symbols: SIPA1L1
• Immunogen: Recombinant protein corresponding to Human SIPA1L1. Recombinant protein control fragment (Product #RP-89050).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG