Invitrogen™ SIPA1L3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520849

Catalog No. PIPA520849

Description

A suggested positive control is SK-N-SH cell lysate. PA5-20849 can be used with blocking peptide PEP-0963.

Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.

Specifications

• Antigen: SIPA1L3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIPA1L3
• Gene Alias: 2610511M17Rik; CTRCT45; KIAA0545; signal induced proliferation associated 1 like 3; signal-induced proliferation-associated 1 like 3; signal-induced proliferation-associated 1-like protein 3; Sipa1l3; SIPA1-like protein 3; SPA-1-like 3; SPA-1-like protein 3; Spal3; SPAR3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23094, 292771, 74206
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: G3X9J0, O60292
• Gene Symbols: SIPA1L3
• Immunogen: A 15 amino acid peptide from near the amino terminus of human SIPA1L3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG