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Tocris Bioscience™ SiRA 2
SDP

Catalog No. 754460U Shop All Novus Biologicals Products
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Catalog No. Quantity
75-446-0U 60 μg
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Catalog No. 75-446-0U Supplier Tocris Bioscience™ Supplier No. 7544/60U

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Description

Fluorogen for SiRA light-up aptamer. Application: confocal microscopy, SRM (including STED)

Key information: SiRA 2 (silicon rhodamine 2) is a near-infrared (NIR) fluorogen for SiRA light-up aptamer. SiRA 2 enables imaging of single RNA in living cells.

Application: confocal microscopy, super resolution microscopy (SRM) techniques, including super-resolution stimulated emission depletion (STED). Cell permeable.

Properties and Photophysical Data: SiRA 2 is extremely bright, photostable and allows the visualization of mRNA expression in bacteria in no-wash, quencher-free, live-cell imaging experiments. Excitation and emission maxima (λ) are 649 nM and 662 nM, respectively; quantum yield = 0.98; extinction coefficient = 86,000 M-1cm-1; KD = 403 nM.

Reconstitute in 200 μL for a 0.5 mM stock solution. A typical working concentration for this product is 500 nM, see references provided for more details.

We recommend using 5mM Mg2+ (MgCl2 or MgSO4) in all buffers/media for maximum fluorescence intensity.

Specifications

Chemical Name or Material (5-((2-(2-(2-Aminoethoxy)ethoxy)ethyl)carbamoyl)-2-(7-(dimethylamino)-3-(dimethyliminio)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)benzoate)
CAS 2365417-91-8
Quantity 60 μg
Target Light-up Aptamers
Molecular Formula C33H42N4O5Si
Purity 0.98
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