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Invitrogen™ SIRP beta/gamma Chimeric Recombinant Rabbit Monoclonal Antibody (OX117)
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Catalog No. PIMA547960
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200 μg
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Catalog No. Quantity
PIMA547960 200 μg
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Catalog No. PIMA547960 Supplier Invitrogen™ Supplier No. MA547960
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody binds to human SIRP-beta and gamma.

SIRP beta and SIRP gamma are two members of the signal regulatory protein (SIRP) family. These proteins are transmembrane receptors that are expressed on the surface of various cells, including immune cells and neurons. The function of SIRP beta and SIRP gamma is to regulate cellular signaling pathways that are involved in immune responses, cell adhesion, and phagocytosis. Specifically, these proteins interact with the protein tyrosine phosphatase SHP-1, which is a negative regulator of immune cell activation. By binding to SHP-1, SIRP beta and SIRP gamma can inhibit immune cell activation and promote immune tolerance. In addition to their role in immune regulation, SIRP beta and SIRP gamma have also been implicated in neuronal signaling and synaptic plasticity. These proteins are thought to play a role in the formation and maintenance of synapses, as well as in the regulation of neuronal activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIRP beta/gamma Chimeric
Applications ELISA, Flow Cytometry, Immunoprecipitation
Classification Recombinant Monoclonal
Clone OX117
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene SIRPB1
Gene Accession No. O00241, Q9P1W8
Gene Symbols SIRPB1, SIRPG
Host Species Rabbit
Immunogen Recombinant human SIRPgamma:CD4 fusion protein.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10326, 55423
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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