Invitrogen™ SIRP beta/gamma Chimeric Recombinant Rabbit Monoclonal Antibody (OX117)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA547960

Catalog No. PIMA547960

Description

Specificity: This antibody binds to human SIRP-beta and gamma.

SIRP beta and SIRP gamma are two members of the signal regulatory protein (SIRP) family. These proteins are transmembrane receptors that are expressed on the surface of various cells, including immune cells and neurons. The function of SIRP beta and SIRP gamma is to regulate cellular signaling pathways that are involved in immune responses, cell adhesion, and phagocytosis. Specifically, these proteins interact with the protein tyrosine phosphatase SHP-1, which is a negative regulator of immune cell activation. By binding to SHP-1, SIRP beta and SIRP gamma can inhibit immune cell activation and promote immune tolerance. In addition to their role in immune regulation, SIRP beta and SIRP gamma have also been implicated in neuronal signaling and synaptic plasticity. These proteins are thought to play a role in the formation and maintenance of synapses, as well as in the regulation of neuronal activity.

Specifications

• Antigen: SIRP beta/gamma Chimeric
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: O00241, Q9P1W8
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 10326, 55423
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Immunoprecipitation
• Clone: OX117
• Conjugate: Unconjugated
• Gene: SIRPB1
• Gene Symbols: SIRPB1, SIRPG
• Immunogen: Recombinant human SIRPgamma:CD4 fusion protein.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG κ