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Invitrogen™ SIRT1 Monoclonal Antibody (7-C5-B2)
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Catalog No. PIMA532912
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100 μL
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Catalog No. Quantity
PIMA532912 100 μL
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Catalog No. PIMA532912 Supplier Invitrogen™ Supplier No. MA532912
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Description

Mouse Monoclonal Antibody

SIRT1 Monoclonal Antibody for ICC/IF, IHC (P), Western Blot

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
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Specifications

Antigen SIRT1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 7-C5-B2
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% Glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene SIRT1
Gene Accession No. Q923E4, Q96EB6
Gene Alias 75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Gene Symbols SIRT1
Host Species Mouse
Immunogen Synthetic peptide within Human SIRT1 aa 698-747.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23411, 93759
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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