SIRT1 Mouse anti-Human, Clone: OTI1H1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF809831

Catalog No. 50-166-9737

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metobolism, apoptosis, and authopahy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5′-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).

Specifications

• Antigen: SIRT1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SIRT1
• Gene Alias: SIR2, SIR2L1, SIR2alpha
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23411
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI1H1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q96EB6
• Gene Symbols: SIRT1
• Immunogen: Human recombit protein fragment corresponding to amino acids 552-676 of human SIRT1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1