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SIRT1/sirtuin 1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984601
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50-198-4601 100 μL
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Catalog No. 50-198-4601 Supplier Bioss Supplier No. BS2257R
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Description

Rabbit Polyclonal Antibody

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5′-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).

Specifications

Antigen SIRT1/sirtuin 1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SIRT1
Gene Accession No. Q96EB6
Gene Alias 75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; Sir2; Sir2a; SIR2alpha; Sir2l1; sir2-like 1; SIR2-like protein 1; SIRT1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Gene Symbols SIRT1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SIRT1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23411
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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