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SIRT2 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA125472
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100 μL
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PIPA125472 100 μL
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Catalog No. PIPA125472 Supplier Thermo Scientific Supplier No. PA125472

Description

Rabbit Polyclonal Antibody

Recommended positive controls: NIH3T3. Predicted molucular weight of 43 kDa.

The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIRT2
Applications Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1.33 mg/mL
Conjugate Unconjugated
Formulation 0.01M PBS with 1% BSA and 15mM sodium azide; pH 7.4
Gene SIRT2
Gene Accession No. Q8IXJ6, Q8VDQ8
Gene Alias 5730427M03Rik; 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2; SIR2L; SIR2L2; SIR2-like protein 2; sir2-related protein type 2; Sirt2; sirtuin 2; sirtuin type 2; sirtuin-2
Gene Symbols SIRT2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the C-terminal residues 722-737 of mouse SIR2/SIRT2, with a C-terminal added lysine.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22933, 64383
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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