Invitrogen™ SIRT5 Recombinant Rabbit Monoclonal Antibody (JJ084-01)

Catalog No.	Quantity
PIMA532464	100 μL

Catalog No. PIMA532464 Supplier Invitrogen™ Supplier No. MA532464

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

Specifications

• Antigen: SIRT5
• Applications: Western Blot
• Classification: Recombinant Monoclonal
• Clone: JJ084-01
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene: SIRT5
• Gene Accession No.: Q8K2C6, Q9NXA8
• Gene Alias: 0610012J09Rik; 1500032M05Rik; AV001953; FLJ36950; HAMAP-Rule:MF_03160}; hypothetical protein LOC507347; NAD-dependent deacetylase sirtuin-5; NAD-dependent deacetylase sirtuin-5-like protein; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255; Regulatory protein SIR2 homolog 5; regulatory protein SIR2 homolog 5 {ECO:0000255; si:ch211-121a2.1; silent mating type information regulation 2, S.cerevisiae, homolog 5; Sir2l5; sir2-like 5; SIR2-like protein 5; SIR2-like protein 5 {ECO:0000255; Sirt5; sirtuin; sirtuin 5; sirtuin type 5; zgc:92288
• Gene Symbols: SIRT5
• Host Species: Rabbit
• Immunogen: Recombinant protein within Human SIRT5 aa 1-160.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23408, 68346
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG