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Invitrogen™ SIT Monoclonal Antibody (SIT-01)
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Catalog No. 01676041
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100 μg
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Catalog No. Quantity
01-676-041 100 μg
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Catalog No. 01-676-041 Supplier Invitrogen™ Supplier No. MA119285
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Description

Mouse Monoclonal Antibody

This antibody reacts with murine SIT. Western Blot: Reducing conditions.

SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
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Specifications

Antigen SIT
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone SIT-01
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene SIT1
Gene Accession No. Q9Y3P8
Gene Alias gp30/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SHP2 interacting transmembrane adaptor; SHP-2 interacting transmembrane adaptor protein; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; signaling threshold regulating transmembrane adaptor 1; signaling threshold-regulating transmembrane adapter 1; SIT; SIT1; SIT-R; suppression inducing transmembrane adaptor 1; suppression-inducing transmembrane adapter 1
Gene Symbols SIT1
Host Species Mouse
Immunogen Bacterially produced, recombinant, intracellular fragment of human SIT.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27240
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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