Invitrogen™ SIT Monoclonal Antibody (SIT-01)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119285

Catalog No. 01-676-041

Description

This antibody reacts with murine SIT. Western Blot: Reducing conditions.

SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.

Specifications

• Antigen: SIT
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: Q9Y3P8
• Gene Symbols: SIT1
• Immunogen: Bacterially produced, recombinant, intracellular fragment of human SIT.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunoprecipitation, Western Blot
• Clone: SIT-01
• Conjugate: Unconjugated
• Gene: SIT1
• Gene Alias: gp30/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SHP2 interacting transmembrane adaptor; SHP-2 interacting transmembrane adaptor protein; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; signaling threshold regulating transmembrane adaptor 1; signaling threshold-regulating transmembrane adapter 1; SIT; SIT1; SIT-R; suppression inducing transmembrane adaptor 1; suppression-inducing transmembrane adapter 1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 27240
• Content And Storage: 4°C, do not freeze
• Form: Liquid