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Invitrogen™ SIX5 Polyclonal Antibody
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Catalog No. PIPA575417
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100 μL
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PIPA575417 100 μL
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Catalog No. PIPA575417 Supplier Invitrogen™ Supplier No. PA575417
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development, Six5 is involved in regulation of organogenesis and in maintenance of retinal formation. Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIX5
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide; pH 7.2
Gene Six5
Gene Accession No. P70178, Q8N196
Gene Alias BOR2; DM locus-associated homeodomain protein; DM locus-associated homeodomain protein homolog; DMAHP; dystrophia myotonica-associated homeodomain protein; homeobox protein SIX5; MDMAHP; Sine oculis homeobox homolog 5; sine oculis-related homeobox 5; sine oculis-related homeobox 5 homolog; SIX homeobox 5; Six5; TrexBF
Gene Symbols Six5
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 205-256 of Human Six5.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147912, 20475, 308406
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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