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Invitrogen™ SIX5 Polyclonal Antibody
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Catalog No. PIPA590859
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PIPA590859 100 μL
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Catalog No. PIPA590859 Supplier Invitrogen™ Supplier No. PA590859
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MATLPAEPSA GPAAGGEAVA AAAATEEEEE EARQLLQTLQ AAEGEAAAAA GAGAGAAAAG AEGPGSPGVP GSPPEAASEP PTGLRFSPEQ VACVCEALLQ AGHAGRLSRF LGALPPAERL RGSDPVLRAR ALVAFQRGEY AELYRLLESR PFPAAHHAFL QDLYLRARYH; Positive Samples: Mouse eye, Rat eye; Cellular Location: Cytoplasm, Nucleus.

Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development, Six5 is involved in regulation of organogenesis and in maintenance of retinal formation. Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIX5
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.71 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Six5
Gene Accession No. P70178
Gene Alias BOR2; DM locus-associated homeodomain protein; DM locus-associated homeodomain protein homolog; DMAHP; dystrophia myotonica-associated homeodomain protein; homeobox protein SIX5; MDMAHP; Sine oculis homeobox homolog 5; sine oculis-related homeobox 5; sine oculis-related homeobox 5 homolog; SIX homeobox 5; Six5; TrexBF
Gene Symbols Six5
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human SIX5 (NP_7870712).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20475, 308406
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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