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Tocris Bioscience™ SJ 1008030
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Catalog No. 76752
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2 mg
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76-752 2 mg
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Catalog No. 76-752 Supplier Tocris Bioscience™ Supplier No. 7675/2
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Description

Selective JAK2 Degrader (PROTAC™)

SJ 1008030 is a potent and selective JAK2 Degrader (PROTAC®). This compound shows potent antileukemic efficacy in CRLF2r ALL (Acute Lymphoblastic Leukemia) cell lines (EC50 = 5.4 nM). SJ 1008030 induces dose-dependent JAK2 degradation (IC50 = 32.05 nM) in xenograft models of kinase-driven ALL, with no effect on GSPT1 levels.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1 H-pyrazol-4-yl)-7 H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate
Quantity 2 mg
Target Active Degraders
Molecular Formula C42H43N13O7S.CF3CO2H
Purity 0.98
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