Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 76752

Tocris Bioscience™ SJ 1008030
GREENER_CHOICE

Catalog No. 76752
Click to view available options
Quantity:
2 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective JAK2 Degrader (PROTAC™)

SJ 1008030 is a potent and selective JAK2 Degrader (PROTAC®). This compound shows potent antileukemic efficacy in CRLF2r ALL (Acute Lymphoblastic Leukemia) cell lines (EC50 = 5.4 nM). SJ 1008030 induces dose-dependent JAK2 degradation (IC50 = 32.05 nM) in xenograft models of kinase-driven ALL, with no effect on GSPT1 levels.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1 H-pyrazol-4-yl)-7 H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate
Quantity 2 mg
Target Active Degraders
Molecular Formula C42H43N13O7S.CF3CO2H
Purity 0.98
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.