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Tocris Bioscience™ SJ 10542
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Catalog No. 77272
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77-272 2 mg
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Catalog No. 77-272 Supplier Tocris Bioscience™ Supplier No. 7727/2
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Description

Potent and selective JAK2/3 Degrader (PROTAC™)

SJ 10542 is a potent and selective JAK2/3 Degrader (PROTAC™) (DC50 values are 11 nM and 14 nM for JAK3 and JAK2, respectively), it uses a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter. SJ 10542 displays high selectivity over GSPT1 and other members of the JAK family. SJ 10542 is active in cytotoxicity assays with PDX models (IC50 values <120 nM).

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide
CAS 2789678-92-6
Quantity 2 mg
Target Active Degraders
Molecular Formula C41H46N12O5S
Purity 97%
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