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Tocris Bioscience™ SJ 3149

Catalog No. 81415
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5 mg
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Catalog No.
81-415 5 mg
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Catalog No. 81-415 Supplier Tocris Bioscience™ Supplier No. 8141/5
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Description

Potent and selective CK1α molecular glue Degrader

SJ 3149 is a potent and selective CK1α molecular glue Degrader (DC50 = 3.7 nM; Dmax 95% in MOLM-13 cells). SJ 3149 induced near-complete degradation of the CK1α protein (DC50 = 6 nM at 4 hours). Potently inhibits the viability of MOLM-13 cells (IC50 = 13 nM). SJ 3149 displays a broad antiproliferative activity profile on a panel of acute leukemia and solid tumor cell lines. In vivo, SJ 3149 degrades CK1α protein levels in NSG mice transplanted with MOLM-13 cells. SJ 3149 shows 76% orally bioavailability.

Specifications

Chemical Name or Material 3-(5-(Benzo[d]isoxazol-3-ylamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS 3026986-17-1
Quantity 5 mg
Target Molecular Glues
Molecular Formula C20H16N4O4
Purity 0.98
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