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Tocris Bioscience™ SJF 1528
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Catalog No. 72625
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72-625 5 mg
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Catalog No. 72-625 Supplier Tocris Bioscience™ Supplier No. 7262/5
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Description

Potent EGFR PROTAC™; also degrades HER2

SJF 1528 is a potent EGFR PROTAC™ Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. SJF 1528 comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells). PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material (2 S,4 R)-1-(-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 2230821-38-0
Quantity 5 mg
Target Active Degraders
Molecular Formula C55H57ClFN7O8S
Purity 0.98
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