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Tocris Bioscience™ SJFa SJFalpha SJFalpha
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Catalog No. 72685
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective p38α PROTAC™

SJFα is a potent and selective p38α PROTAC™ Degrader (DC50 = 7.16 nM and Dmax = 97.4%). SJFα comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Displays significantly lower potency degradation at p38δ (DC50 = 299 nM). Exhibits no significant degradation of p38β or γ. or related MAPKs, ERK1/2, or JNK1/2. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material N-(3-Fluoro-4-((7-(4-(4-(2-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarb
CAS 2254609-27-1
Quantity 5 mg
Target Active Degraders
Molecular Formula C59H67F2N7O11S
Purity 0.98
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