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  5. Tocris Bioscience™ SK 216

Tocris Bioscience™ SK 216
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Catalog No. 618710
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10 mg
50 mg
Catalog No. Quantity
61-871-0 10 mg
61-875-0 50 mg
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Catalog No. 61-871-0

Supplier: Tocris Bioscience™ 6187/10

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Description

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

SK 216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. Inhibits VEGF-induced migration and tube formation in HUVECs. Also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Reduces size and weight of subcutaneous tumors, and inhibits metastasis and angiogenesis in vivo. Reduces bleomycin-induced pulmonary fibrosis in vivo. Orally bioavailable.

Specifications

Chemical Name or Material 2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt
CAS 654080-03-2
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C29H29NO6Na2
Formula Weight Observed MW: 533.52
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