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Tocris Bioscience™ SK 216
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Catalog No. 618750
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61-875-0 50 mg
61-871-0 10 mg
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Catalog No. 61-875-0 Supplier Tocris Bioscience™ Supplier No. 6187/50
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Description

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

SK 216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. Inhibits VEGF-induced migration and tube formation in HUVECs. Also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Reduces size and weight of subcutaneous tumors, and inhibits metastasis and angiogenesis in vivo. Reduces bleomycin-induced pulmonary fibrosis in vivo. Orally bioavailable.

Specifications

Chemical Name or Material 2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt
CAS 654080-03-2
Assay Percent Range >98%
Quantity 50 mg
Molecular Formula C29H29NO6Na2
Formula Weight Observed MW: 533.52
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