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Invitrogen™ SKA1 Polyclonal Antibody
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Catalog No. PIPA520817
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100 μg
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Catalog No. Quantity
PIPA520817 100 μg
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Catalog No. PIPA520817 Supplier Invitrogen™ Supplier No. PA520817
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Description

Rabbit Polyclonal Antibody

A suggested positive control is A549 cell lysate. PA5-20817 can be used with blocking peptide PEP-0931.

Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SKA1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SKA1
Gene Accession No. B0BN28, Q96BD8, Q9CPV1
Gene Alias 2810433K01Rik; AV117428; C18orf24; RGD1310784; SKA1; spindle and kinetochore associated complex subunit 1; spindle and kinetochore-associated protein 1; spindle and KT (kinetochore) associated 1
Gene Symbols SKA1
Host Species Rabbit
Immunogen A 13 amino acid peptide from near the carboxy terminus of human SKA1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 220134, 291441, 66468
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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