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Invitrogen™ SKA2 Polyclonal Antibody
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Catalog No. PA548419
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400 μL
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Catalog No. Quantity
PA548419 400 μL
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Catalog No. PA548419 Supplier Invitrogen™ Supplier No. PA548419
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Description

Rabbit Polyclonal Antibody

Predicted to react with monkey based on sequence homology.

Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SKA2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene SKA2
Gene Accession No. Q8WVK7
Gene Alias 1110001A07Rik; C78640; FAM33A; family with sequence similarity 33, member A; Protein FAM33A; RGD1307084; Ska2; spindle and kinetochore associated complex subunit 2; spindle and kinetochore-associated protein 2; spindle and KT (kinetochore) associated 2
Gene Symbols SKA2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human SKA2.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 348235
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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