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Invitrogen™ SKA3 Polyclonal Antibody
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Catalog No. PIPA5139853
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100 μL
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PIPA5139853 100 μL
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Catalog No. PIPA5139853 Supplier Invitrogen™ Supplier No. PA5139853
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: RTSLVLNSDT CFENLTDPSS PTISSYENLL RTPTPPEVTK IPEDILQLLS KYNSNLATPI AIKAVPPSKR FLKHGQNIRD VSNKEN Highest antigen sequence indentity to the following orthologs: Rat - 58%, Mouse - 45%.

Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Like with SKA1 or SKA2, depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged a metaphase-like state. These SKA3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores, suggesting the SKA complex plays a key role in spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SKA3
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SKA3
Gene Accession No. Q8IX90
Gene Alias C13orf3; F630043A04Rik; RAMA1; RGD1307201; RP11-101P17.12-002; Ska3; spindle and kinetochore associated complex subunit 3; spindle and kinetochore-associated protein 3
Gene Symbols SKA3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SKA3. Recombinant protein control fragment (Product #RP-109000).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 221150
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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