Invitrogen™ SKAP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552164

Catalog No. PIPA552164

Description

Immunogen sequence: GSDKDKQQKG EFAIDGYSVR MNNTLRKDGK KDCCFEISAP DKRIYQFTAA SPKDAEEWVQ QLKFVLQDME SDIIPEDYDE RGELYDDVDH PLPISNPLTS SQPIDDEIYE ELPEEEEDSA PVKVEEQRKM SQDSVHHTSG D Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 82%.

Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.

Specifications

• Antigen: SKAP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SKAP2
• Gene Alias: 2610021A10Rik; AA960083; BB137539; Fyn-associated phosphoprotein SKAP55 homologue; MGC10411; MGC33304; mSKAP55R; PRAP; pyk2/RAFTK-associated protein; RA70; Retinoic acid-induced protein 70; Saps; SCAP2; Scap55r; Skap2; SKAP55 homolog; SKAP55 homologue; SKAP-55HOM; SKAP55-HOM; SKAP55R; SKAP-HOM; src family associated phosphoprotein 2; src family-associated phosphoprotein 2; src kinase associated phosphoprotein 2; src kinase-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; src kinase-associated phosphoprotein of 55-related protein; src-associated adapter protein with PH and SH3 domains; Src-associated adaptor protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8935
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75563
• Gene Symbols: SKAP2
• Immunogen: Recombinant protein corresponding to Human SKAP2. Recombinant protein control fragment (Product #RP-88612).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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