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Invitrogen™ SKAP2 Polyclonal Antibody
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Catalog No. PIPA5120393
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100 μL
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PIPA5120393 100 μL
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Catalog No. PIPA5120393 Supplier Invitrogen™ Supplier No. PA5120393
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Description

Rabbit Polyclonal Antibody

Positive test controls include: Mouse lung. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: MPNPSSTSSP YPLPEEIRNL LADVETFVAD ILKGENLSKK AKEKRESLIK KIKDVKSIYL QEFQDKGDAE DGEEYDDPFA GPPDTISLAS ERYDKDDEAP SDGAQFPPIA AQDLPFVLKA.

Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SKAP2
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.24 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SKAP2
Gene Accession No. O75563, Q3UND0, Q920G0
Gene Alias 2610021A10Rik; AA960083; BB137539; Fyn-associated phosphoprotein SKAP55 homologue; MGC10411; MGC33304; mSKAP55R; PRAP; pyk2/RAFTK-associated protein; RA70; Retinoic acid-induced protein 70; Saps; SCAP2; Scap55r; Skap2; SKAP55 homolog; SKAP55 homologue; SKAP-55HOM; SKAP55-HOM; SKAP55R; SKAP-HOM; src family associated phosphoprotein 2; src family-associated phosphoprotein 2; src kinase associated phosphoprotein 2; src kinase-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; src kinase-associated phosphoprotein of 55-related protein; src-associated adapter protein with PH and SH3 domains; Src-associated adaptor protein
Gene Symbols SKAP2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SKAP2 (NP_003921.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 155183, 54353, 8935
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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