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SKI 178, Tocris Bioscience™

Catalog No. 545250
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50 mg
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Catalog No. Quantity
54-525-0 50 mg
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Catalog No. 54-525-0 Supplier R&D Systems Supplier No. 5452/50
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Description

Non-lipid sphingosine kinase 1 (SphK1) inhibitor

Non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). Induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Active in vivo.

Chemical Identifiers

Physical Form Solid
Synonym SKI 178
Solubility Information Soluble to 100mM in DMSO
Formula Weight 394.42
Linear Formula C21H22N4O4
CAS 1259484-97-3
Chemical Name or Material N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide

Specifications

Molecular Formula C21H22N4O4
Quantity 50 mg
InChI Key GMFUWEBOUKIKRP-LPYMAVHISA-N
SMILES CC(=NNC(=O)C1=CC(=NN1)C2=CC=C(C=C2)OC)C3=CC(=C(C=C3)OC)OC
IUPAC Name N-[(E)-1-(3,4-dimethoxyphenyl)ethylideneamino]-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
Molecular Weight (g/mol) 394.431
PubChem CID 5342941
Percent Purity >98%

Safety and Handling

Recommended Storage Store at −20°C
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