SKIL Monoclonal Antibody (OTI2C5), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-8137	100 μL

Catalog No. 50-167-8137 Supplier OriGene Supplier No. TA800164

Description

Mouse Monoclonal Antibody

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.

Specifications

• Antigen: SKIL
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2C5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: SKIL
• Gene Accession No.: P12757
• Gene Alias: SNO, SnoA, SnoI, SnoN
• Gene Symbols: SKIL
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 307-684 of human SKIL produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6498
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1