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SKIL Monoclonal Antibody (OTI3A7), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA800158

Encompass_Preferred

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Catalog No. 50-167-8132


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Description

Description

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
Specifications

Specifications

SKIL
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P12757
SKIL
Human recombit protein fragment corresponding to amino acids 307-684 of human SKIL produced in E.coli.
100 μL
Primary
Human
Antibody
IgG1
Western Blot
OTI3A7
Unconjugated
SKIL
SNO, SnoA, SnoI, SnoN
Mouse
Affinity Chromatography
RUO
6498
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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