SKIL Monoclonal Antibody (OTI3A7), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA800158

Catalog No. 50-167-8132

Description

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.

Specifications

• Antigen: SKIL
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P12757
• Gene Symbols: SKIL
• Immunogen: Human recombit protein fragment corresponding to amino acids 307-684 of human SKIL produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI3A7
• Conjugate: Unconjugated
• Gene: SKIL
• Gene Alias: SNO, SnoA, SnoI, SnoN
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6498
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid