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R&D Systems™ SKLB-11A
SDP

Catalog No. RD10188000 Shop All Novus Products
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10 mg
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RD10188000 10 mg
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Catalog No. RD10188000 Supplier R&D Systems™ Supplier No. 8979/10

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Description

A Tocris product, part of R&D Systems.

SKLB-11A is a potent and selective allosteric activator of SIRT3 (Kd = 4.7 μM), enhancing its deacetylation activity (EC50 = 22 μM). SKLB-11A showed no binding to SIRT5 or SIRT6, and low binding affinity for SIRT1 and SIRT2 (Kd values exceeded 200 μM, 40 times lower than its affinity for SIRT3).

In vitro and in vivo, SKLB-11A induces autophagy, leading to cardioprotective efficacy.

Specifications

Chemical Name or Material Methyl 2-amino-1-[(4-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate
CAS 433953-86-7
Quantity 10 mg
Product Line Tocris
Target Class III Histone Deacetylases Inhibitors
Molecular Formula C19H15FN4O2
Purity 98%
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