Invitrogen™ SKP1 Recombinant Rabbit Monoclonal Antibody (JM27-37)

Catalog No.	Quantity
PIMA532744	100 μL

Catalog No. PIMA532744 Supplier Invitrogen™ Supplier No. MA532744

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteasome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Specifications

• Antigen: SKP1
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: JM27-37
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene: SKP1
• Gene Accession No.: P63208, Q6PEC4, Q9WTX5
• Gene Alias: 15kDa; 2610043E24Rik; 2610206H23Rik; cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; cyclin-A/CDK2-associated protein p19; EMC19; MGC34403; OCP2; OCP-2; OCP-II; OCP-II protein; organ of Corti protein 2; Organ of Corti protein II; p19A; p19Skp1; polypeptide 1-like; RNA polymerase II elongation factor-like protein; RNA polymerase II elongation factor-like protein OCP2; SIII; Skp1; Skp1a; S-phase kinase-associated protein 1; S-phase kinase-associated protein 1A; TCEB1L; transcription elongation factor B polypeptide 1-like
• Gene Symbols: SKP1, Skp1a
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human Skp1 aa 106-155.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21402, 287280, 6500
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG