SKP2 Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-156-2583	20 μL

Catalog No. 50-156-2583 Supplier Bethyl Laboratories, Inc Supplier No. A302436AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.

Specifications

• Antigen: SKP2
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: SKP2
• Gene Accession No.: Q13309
• Gene Alias: CDK2/cyclin A-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; OTTHUMP00000221389; S-phase kinase-associated protein 2; cyclin A/CDK2-associated protein p45; cyclin-A/CDK2-associated protein p45; p45skp2
• Gene Symbols: SKP2
• Host Species: Rabbit
• Immunogen: Between 1 and 50
• Purification Method: Antigen affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6502
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG