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SKP2 Rabbit anti-Human, Mouse, Rat, Unconjugated, Clone: ARC0886, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535433

Catalog No. PIMA535433


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Description

Description

Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.
Specifications

Specifications

SKP2
ARC0886
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
Q13309, Q9Z0Z3
4930500A04Rik; Cyclin-A/CDK2-associated protein p45; FBL1; F-box protein Skp2; F-box/LRR-repeat protein 1; F-box/WD-40 protein 1; FBXL1; FLB1; FWD1; MGC1366; OTTHUMP00000221389; p45; p45skp2; RGD1562456; Skp2; S-phase kinase-associated protein 2
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
27401, 294790, 6502
Western Blot
Unconjugated
SKP2
Liquid
SKP2
A synthesized peptide derived from human SKP2
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
SDS
Documents
Product Certifications
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