Invitrogen™ SLA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567335

Catalog No. PIPA567335

Description

Immunogen sequence: PCLTQSTAAPA VRASSSPVTL RQKTVDWRRV SRLQEDPEGT ENPLGVDESL FSYGLRESIA SYLSLTSEDN TSFDRKKKSI SLMYGGSKRK SSFFSSPP Highest antigen sequence identity to the following orthologs - mouse 73%, rat 71%.

SLAP also known as Src-like-adapter protein 1 is a 276 amino acid containing adapter protein, functioning as a negative regulator of T-cell receptor (TCR) signaling. SLAP belonging to the SRC family of cytoplasmic tyrosine kinases contains a SH2 domain and a SH3 domain. This cytoplasmic protein colocalizes with endosomes and is known to inhibit T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. It acts as a negative regulator of positive selection and mitosis of T-cells. SLAP may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Expression of SLAP is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas but is high in lung and fetal brain.

Specifications

• Antigen: SLA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLA
• Gene Alias: hSLAP; Sla; SLA1; SLAP; Slap1; Slap-1; Src like adaptor; src-like adaptor; src-like-adapter; Src-like-adapter protein 1; Src-like-adaptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6503
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q13239
• Gene Symbols: SLA
• Immunogen: Recombinant Human SLA. Recombinant protein control fragment (Product #RP-107983).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG