SLAMF7 Mouse anti-Human, Clone: OTI3B3, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807414

Catalog No. 50-166-8265

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.

Specifications

• Antigen: SLAMF7
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SLAMF7
• Gene Alias: 19A, CD319, CRACC, CS1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57823
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3B3
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9NQ25
• Gene Symbols: SLAMF7
• Immunogen: Full length human recombit protein of human SLAMF7 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b