SLC14A2/UT-A Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1679	100 μL

Catalog No. 50-198-1679 Supplier Bioss Supplier No. BS11801R

Description

Rabbit Polyclonal Antibody

Water balance is tightly regulated in the kidneys. Through urinary concentration mechanisms, the kidney prevents the unnecessary excrement of water, thereby protecting the body from dehydration. UT-A (Urea transporter, kidney), also known as SLC14A2 and HUT2, is a 920 amino acid multi-pass membrane protein that functions as a specialized low-affinity vasopressin-regulated urea-transporter. Expressed in the inner medulla of the kidney and localized to the apical membrane, UT-A mediates rapid transepithelial urea transport across the inner medullary collecting duct. There are two isoforms of UT-A that are produced as a result of alternative splicing events. Isoform 1 interacts with Snapin, a SNARE-associated protein, which is thought to help in its recruitment to the plasma membrane. Interestingly, isoform 1 expression is induced by low protein in the diet, whereas isoform 2 expression is induced by dehydration.

Specifications

• Antigen: SLC14A2/UT-A
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: SLC14A2
• Gene Accession No.: Q15849
• Gene Symbols: SLC14A2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human SLC14A2/UT-A.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8170
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG