Invitrogen™ SLC16A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101676

Catalog No. PIPA5101676

Description

Antibody detects endogenous levels of total SLC16A2.

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiency (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.

Specifications

• Antigen: SLC16A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Slc16a2
• Gene Alias: AHDS; AW105741; DXS128; DXS128E; MCT 7; MCT 8; MCT7; MCT8; monocarboxylate transporter; monocarboxylate transporter 7; Monocarboxylate transporter 8; Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter); MRX22; SLC16A2; solute carrier family 16 (monocarboxylic acid transporters), member 2; solute carrier family 16 member 2; solute carrier family 16, member 2 (monocarboxylic acid transporter 8); solute carrier family 16, member 2 (thyroid hormone transporter); X-linked PEST-containing transporter; XPCT
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20502, 259248, 6567
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O70324, P36021, Q8K1P8
• Gene Symbols: Slc16a2
• Immunogen: A synthesized peptide derived from human SLC16A2(Accession P36021), corresponding to amino acid residues N111-V161.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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