Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA5101676

Invitrogen™ SLC16A2 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA5101676
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA5101676 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA5101676 Supplier Invitrogen™ Supplier No. PA5101676
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SLC16A2.

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiency (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC16A2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Slc16a2
Gene Accession No. O70324, P36021, Q8K1P8
Gene Alias AHDS; AW105741; DXS128; DXS128E; MCT 7; MCT 8; MCT7; MCT8; monocarboxylate transporter; monocarboxylate transporter 7; Monocarboxylate transporter 8; Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter); MRX22; SLC16A2; solute carrier family 16 (monocarboxylic acid transporters), member 2; solute carrier family 16 member 2; solute carrier family 16, member 2 (monocarboxylic acid transporter 8); solute carrier family 16, member 2 (thyroid hormone transporter); X-linked PEST-containing transporter; XPCT
Gene Symbols Slc16a2
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLC16A2(Accession P36021), corresponding to amino acid residues N111-V161.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20502, 259248, 6567
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.