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Invitrogen™ SLC1A6 Polyclonal Antibody
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Catalog No. PIPA5115153
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PIPA5115153 100 μL
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Catalog No. PIPA5115153 Supplier Invitrogen™ Supplier No. PA5115153
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total EAAT4.

Slc1a6 encodes a protein that is a glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Slc1a6 functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Slc1a6 also mediates Cl(-) flux that is not coupled to amino acid transport and this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Further, Slc1a6 [lays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC1A6
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene SLC1A6
Gene Accession No. O35544, O35921, P48664
Gene Alias EAAT4; Excitatory amino acid transporter 4; high affinity aspartate/glutamate transporter; high-affinity neuronal glutamate transporter; Slc1a6; Sodium-dependent glutamate/aspartate transporter; solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6; solute carrier family 1 member 6; solute carrier family 1, member 6
Gene Symbols SLC1A6
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLC1A6(Accession P48664), corresponding to amino acid residues I514-M564.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20513, 6511, 84012
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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