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Invitrogen™ SLC22A18 Polyclonal Antibody
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Catalog No. PIPA5106523
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100 μL
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PIPA5106523 100 μL
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Catalog No. PIPA5106523 Supplier Invitrogen™ Supplier No. PA5106523
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ORCTL-2.

ORCTL2 (organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A or SLC22A18, is a 424 amino acid multi-pass membrane protein that localizes at the apical membrane surface of renal proximal tubules. ORCTL2 is expressed at high levels in the kidney, liver, colon and in fetal renal proximal tubules and present at lower levels in heart, brain and lung. Belonging to the major facilitator superfamily, ORCTL2 may act as a transporter of organic cations based on a proton efflux antiport mechanism and may also play a role in the transport of chloroquine and quinidine-related compounds in kidney. Defects in ORCTL2 are associated with breast and lung cancer and are the cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC22A18
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SLC22A18
Gene Accession No. Q96BI1
Gene Alias AW260131; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; BWR1A; BWSCR1A; Efflux transporter-like protein; HET; imprinted multi-membrane spanning polyspecific transporter-related protein 1; imprinted multi-membrane-spanning polyspecific transporter-related protein 1; Impt1; ITM; Multi-membrane-spanning polyspecific transporter; ORCTL2; ORCTL-2; Organic cation transporter-like protein 2; organic cationic transporter-like 2; p45 Beckwith-Wiedemann region 1A; p45-Beckwith-Wiedemann region 1 A; p45-BWR1A; SLC22A18; SLC22A1L; solute carrier family 22 (organic cation transporter), member 18; Solute carrier family 22 member 18; Solute carrier family 22 member 1-like; solute carrier family 22, member 18; TSSC5; tumor suppressing subtransferable candidate 5; tumor-suppressing STF cDNA 5 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein
Gene Symbols SLC22A18
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLC22A18(Accession Q96BI1), corresponding to amino acid residues F391-R424.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5002
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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