Invitrogen™ SLC22A2 Monoclonal Antibody (640438)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524289

Catalog No. PIMA524289

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.

Specifications

• Antigen: SLC22A2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O15244
• Gene Symbols: Slc22a2
• Immunogen: NS0 mouse myeloma cell line transfected with human SLC-22A2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin)
• Clone: 640438
• Conjugate: Unconjugated
• Gene: Slc22a2
• Gene Alias: 2-Oct; hOCT2; OCT2; OCT2r; Orct2; Organic cation transporter 2; rOCT2; Slc22a2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22 member 2; solute carrier family 22, member 2
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 6582
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized