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Invitrogen™ SLC22A2 Monoclonal Antibody (CL0631)
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Catalog No. PIMA524612
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100 μL
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PIMA524612 100 μL
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Catalog No. PIMA524612 Supplier Invitrogen™ Supplier No. MA524612
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Description

Mouse Monoclonal Antibody

Immunogen sequence: ESPRWLISQN KNAEAMRIIK HIAKKNGKSL PASLQRLRLE EETGKKLNPS FLDLVRTPQI R Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 77%. Binds to an epitope located within the peptide sequence KNAEAMRIIKHIAKK as determined by overlapping synthetic peptides.

Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC22A2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone CL0631
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Slc22a2
Gene Accession No. O15244
Gene Alias 2-Oct; hOCT2; OCT2; OCT2r; Orct2; Organic cation transporter 2; rOCT2; Slc22a2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22 member 2; solute carrier family 22, member 2
Gene Symbols Slc22a2
Host Species Mouse
Immunogen Recombinant protein fragment of Human SLC22A2 (Product #RP-101762)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6582
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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