Invitrogen™ SLC22A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119932

Catalog No. PIPA5119932

Description

Positive Control: HepG2 cell lysate, 293T cell lysate, rat brain tissue lysate, mouse kidney tissue lysate, mouse brain tissue lysate. Subcellular Location: Membrane.

Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.

Specifications

• Antigen: SLC22A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Slc22a2
• Gene Alias: 2-Oct; hOCT2; OCT2; OCT2r; Orct2; Organic cation transporter 2; rOCT2; Slc22a2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22 member 2; solute carrier family 22, member 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20518, 29503, 6582
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O15244, O70577, Q9R0W2
• Gene Symbols: Slc22a2
• Immunogen: Recombinant protein within human SLC22A2 aa 44-150/555 (Extracellular).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG