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Invitrogen™ SLC22A5 Polyclonal Antibody
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Catalog No. PIPA5102460
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PIPA5102460 100 μL
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Catalog No. PIPA5102460 Supplier Invitrogen™ Supplier No. PA5102460
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SLC22A5.

Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC22A5
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SLC22A5
Gene Accession No. O70594, O76082, Q9Z0E8
Gene Alias CDSP; CT1; high-affinity carnitine transporter; high-affinity sodium dependent carnitine cotransporter; high-affinity sodium-dependent carnitine cotransporter; integral membrane transport protein; juvenile visceral steatosis; jvs; Lstpl; Octn2; OCTN2VT; Organic cation/carnitine transporter 2; S22A5; SLC22A5; solute carrier family 22 (organic cation transporter), member 5; solute carrier family 22 (organic cation/carnitine transporter), member 5; solute carrier family 22 member 5; solute carrier family 22, member 5; UST2r
Gene Symbols SLC22A5
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLC22A5(Accession O76082), corresponding to amino acid residues M445-M495.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20520, 29726, 6584
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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