Invitrogen™ SLC22A5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102460

Catalog No. PIPA5102460

Description

Antibody detects endogenous levels of total SLC22A5.

Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.

Specifications

• Antigen: SLC22A5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC22A5
• Gene Alias: CDSP; CT1; high-affinity carnitine transporter; high-affinity sodium dependent carnitine cotransporter; high-affinity sodium-dependent carnitine cotransporter; integral membrane transport protein; juvenile visceral steatosis; jvs; Lstpl; Octn2; OCTN2VT; Organic cation/carnitine transporter 2; S22A5; SLC22A5; solute carrier family 22 (organic cation transporter), member 5; solute carrier family 22 (organic cation/carnitine transporter), member 5; solute carrier family 22 member 5; solute carrier family 22, member 5; UST2r
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20520, 29726, 6584
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O70594, O76082, Q9Z0E8
• Gene Symbols: SLC22A5
• Immunogen: A synthesized peptide derived from human SLC22A5(Accession O76082), corresponding to amino acid residues M445-M495.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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