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Invitrogen™ SLC25A13 Polyclonal Antibody
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Catalog No. PIPA5103678
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PIPA5103678 100 μL
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Catalog No. PIPA5103678 Supplier Invitrogen™ Supplier No. PA5103678
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SLC25A13.

Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD). CTLN2 is an autosomal recessive disease that results from errors in the urea cycle and is characterized by neuropsychiatric symptoms such as loss of memory, seizures and coma. NICCD, a non-lethal disorder, occurs during infancy and is characterized by low birth weight, reduced bile flow, growth retardation and hepatic fibrosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC25A13
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Slc25a13
Gene Accession No. Q9QXX4, Q9UJS0
Gene Alias AI785475; ARALAR2; Calcium-binding mitochondrial carrier protein Aralar2; citrin; CTLN2; Ctrn; Mitochondrial aspartate glutamate carrier 2; RGD1565889; SLC25A13; solute carrier family 25 (aspartate/glutamate carrier), member 13; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13; solute carrier family 25 member 13; solute carrier family 25, member 13; solute carrier family 25, member 13 (citrin)
Gene Symbols Slc25a13
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLC25A13(Accession Q9UJS0), corresponding to amino acid residues L603-K653.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10165, 50799
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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