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Invitrogen™ SLC25A13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521991

Catalog No. PIPA521991


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Description

Description

Recommended positive controls: 293T, A431, HeLa, HepG2, mouse liver, rat liver. Predicted reactivity: Mouse (96%), Xenopus laevis (88%), Chicken (94%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD). CTLN2 is an autosomal recessive disease that results from errors in the urea cycle and is characterized by neuropsychiatric symptoms such as loss of memory, seizures and coma. NICCD, a non-lethal disorder, occurs during infancy and is characterized by low birth weight, reduced bile flow, growth retardation and hepatic fibrosis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SLC25A13
Polyclonal
Unconjugated
Slc25a13
AI785475; ARALAR2; Calcium-binding mitochondrial carrier protein Aralar2; citrin; CTLN2; Ctrn; Mitochondrial aspartate glutamate carrier 2; RGD1565889; SLC25A13; solute carrier family 25 (aspartate/glutamate carrier), member 13; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13; solute carrier family 25 member 13; solute carrier family 25, member 13; solute carrier family 25, member 13 (citrin)
Rabbit
Antigen Affinity Chromatography
RUO
10165, 362322, 50799
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.61 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Q9QXX4, Q9UJS0
Slc25a13
Recombinant fragment corresponding to a region within amino acids 248 and 535 of SLC25A13 (Uniprot ID#Q9UJS0).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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