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Invitrogen™ SLC25A36 Polyclonal Antibody
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Catalog No. PIPA531606
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100 μL
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PIPA531606 100 μL
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Catalog No. PIPA531606 Supplier Invitrogen™ Supplier No. PA531606
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (94%), Xenopus laevis (84%), Pig (95%), Chicken (88%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The SLC25A36 gene is part of the solute carrier family 25 (SLC25), which encodes mitochondrial transport proteins. SLC25A36 specifically functions as a transporter of pyrimidine nucleotides, including deoxynucleotide triphosphates, across the inner mitochondrial membrane. This transport is essential for maintaining mitochondrial DNA synthesis and repair, as well as for the proper functioning of mitochondrial ribonucleotide reductase. The SLC25A36 protein exhibits a characteristic transmembrane structure with six transmembrane helices and a central substrate-binding site. It operates via a mechanism involving substrate binding, conformational changes, and alternating access to the substrate-binding site from either side of the membrane. Dysregulation or mutations in SLC25A36 can lead to mitochondrial dysfunction and are associated with various metabolic disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC25A36
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.84 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene SLC25A36
Gene Accession No. Q922G0, Q96CQ1
Gene Alias C330005L02Rik; PNC2; Slc25a36; solute carrier family 25 (pyrimidine nucleotide carrier ), member 36; solute carrier family 25 (pyrimidine nucleotide carrier), member 36; solute carrier family 25 member 36; solute carrier family 25, member 36
Gene Symbols SLC25A36
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human SLC25A36. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 192287, 55186
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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