Invitrogen™ SLC28A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554023

Catalog No. PIPA554023

Description

Immunogen sequence: MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS WSEAAPKPFS RWRNLQPA Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 59%.

Nucleosides play a role in signaling in several physiologic systems, and synthetic analogs of natural nucleosides are often used to treat neoplastic and viral diseases. Plasma membrane transport of nucleosides is mediated by equilibrative and concentrative nucleoside transporters, which may have specificity for purines or pyrimidines. The deduced human 650 amino acid concentrative nucleoside transporter 1 (CNT1) protein is 83% identical to the rat protein and is expressed in the intestine, kidney and liver. CNT1, also designated solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (SLC28A1), expedites sodium-dependent fluxes of uridine, azidodeoxythymidine (AZT) and adenosine, but not of guanosine or deoxyadenosine, which undergo net renal secretion. CNT1 activity may serve as a putative mechanism for renal reabsorption of physiologic nucleosides and synthetic nucleoside drugs.

Specifications

• Antigen: SLC28A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Slc28a1
• Gene Alias: CNT 1; CNT1; Concentrative nucleoside transporter 1; HCNT1; Na(+)/nucleoside cotransporter 1; SLC28A1; sodium/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; solute carrier family 28 (concentrative nucleoside transporter), member 1; solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; solute carrier family 28 member 1; solute carrier family 28, member 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9154
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O00337
• Gene Symbols: Slc28a1
• Immunogen: Recombinant protein corresponding to Human SLC28A1. Recombinant protein control fragment (Product #RP-90997).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov