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Invitrogen™ SLC28A1 Polyclonal Antibody
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Catalog No. PIPA5104163
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PIPA5104163 100 μL
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Catalog No. PIPA5104163 Supplier Invitrogen™ Supplier No. PA5104163
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SLC28A1.

Nucleosides play a role in signaling in several physiologic systems, and synthetic analogs of natural nucleosides are often used to treat neoplastic and viral diseases. Plasma membrane transport of nucleosides is mediated by equilibrative and concentrative nucleoside transporters, which may have specificity for purines or pyrimidines. The deduced human 650 amino acid concentrative nucleoside transporter 1 (CNT1) protein is 83% identical to the rat protein and is expressed in the intestine, kidney and liver. CNT1, also designated solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (SLC28A1), expedites sodium-dependent fluxes of uridine, azidodeoxythymidine (AZT) and adenosine, but not of guanosine or deoxyadenosine, which undergo net renal secretion. CNT1 activity may serve as a putative mechanism for renal reabsorption of physiologic nucleosides and synthetic nucleoside drugs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC28A1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Slc28a1
Gene Accession No. O00337, Q62674
Gene Alias CNT 1; CNT1; Concentrative nucleoside transporter 1; HCNT1; Na(+)/nucleoside cotransporter 1; SLC28A1; sodium/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; solute carrier family 28 (concentrative nucleoside transporter), member 1; solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; solute carrier family 28 member 1; solute carrier family 28, member 1
Gene Symbols Slc28a1
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLC28A1(Accession O00337), corresponding to amino acid residues G20-R70.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116642, 434203, 9154
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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