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Invitrogen™ SLC28A1 Polyclonal Antibody
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Catalog No. PIPA537223
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100 μL
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Catalog No. Quantity
PIPA537223 100 μL
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Catalog No. PIPA537223 Supplier Invitrogen™ Supplier No. PA537223
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 71 kDa. Purity is >95% by SDS-PAGE.

Nucleosides play a role in signaling in several physiologic systems, and synthetic analogs of natural nucleosides are often used to treat neoplastic and viral diseases. Plasma membrane transport of nucleosides is mediated by equilibrative and concentrative nucleoside transporters, which may have specificity for purines or pyrimidines. The deduced human 650 amino acid concentrative nucleoside transporter 1 (CNT1) protein is 83% identical to the rat protein and is expressed in the intestine, kidney and liver. CNT1, also designated solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (SLC28A1), expedites sodium-dependent fluxes of uridine, azidodeoxythymidine (AZT) and adenosine, but not of guanosine or deoxyadenosine, which undergo net renal secretion. CNT1 activity may serve as a putative mechanism for renal reabsorption of physiologic nucleosides and synthetic nucleoside drugs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC28A1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Slc28a1
Gene Accession No. O00337, Q62674
Gene Alias CNT 1; CNT1; Concentrative nucleoside transporter 1; HCNT1; Na(+)/nucleoside cotransporter 1; SLC28A1; sodium/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; solute carrier family 28 (concentrative nucleoside transporter), member 1; solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; solute carrier family 28 member 1; solute carrier family 28, member 1
Gene Symbols Slc28a1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to residues in human SLC28A1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116642, 434203, 9154
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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