Invitrogen™ Slc30A8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103252

Catalog No. PIPA5103252

Description

Antibody detects endogenous levels of total SLC30A8.

Slc30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of Slc30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes, but no genetic association has been found with Type 1 diabetes. Slc30A8 expression in b-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1 beta.

Specifications

• Antigen: Slc30A8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC30A8
• Gene Alias: C820002P14Rik; LOW QUALITY PROTEIN: uncharacterized protein slc30a8; Slc30a8; solute carrier family 30 (zinc transporter), member 8; solute carrier family 30 member 8; wu:fe49g03; Zinc transporter 8; zinc transporter 8; LOW QUALITY PROTEIN: zinc transporter 8; zinc transporter ZnT-8; Znt8; ZnT-8
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 169026
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8IWU4
• Gene Symbols: SLC30A8
• Immunogen: A synthesized peptide derived from human SLC30A8(Accession Q8IWU4), corresponding to amino acid residues I179-I229.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov